5-(4-bromophenyl)-2-phenyl-7-pyrazolo[1-5-a]pyrimidinamine has been researched along with Edema* in 1 studies
1 other study(ies) available for 5-(4-bromophenyl)-2-phenyl-7-pyrazolo[1-5-a]pyrimidinamine and Edema
| Article | Year |
|---|---|
Molecular docking design and one-pot expeditious synthesis of novel 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines as anti-inflammatory agents.
A series of novel 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines were designed as COX-2 inhibitors by molecular docking studies and their synthesis was accomplished via an expeditious one-pot reaction. Structures of the compounds were established by NMR ((1)H-(13)C), IR spectroscopy and high resolution mass spectrometry. All the eleven compounds have been screened for their in vivo anti-inflammatory activity on rats by carrageenan-induced rat paw edema assay. Correlation studies of calculated moldock score and observed percentage inhibition have also been carried out which concluded that the synthesized 2,5-diarylpyrazolo[1,5-a]pyrimidin-7-amines act as potent anti-inflammatory agents up to the 4th hour of study. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Design; Edema; Male; Molecular Docking Simulation; Molecular Structure; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Structure-Activity Relationship | 2015 |